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335,336,337,338 As for non-malignant endothelial cells at regular oxygen concentrations, lactate activates hypoxia-inducible factor 1 (HIF-1) that enhance s basic fibroblast growth factor (bFGF) and vascular endothelial growth factor receptor 2 (VEGFR2) expression, which synergizes with lactate-induced VEGF secretion

And finally 12mg for those randomized to the highest dose group

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In particular, the occurrence of this process in immune cells impacts both their numbers and effectiveness, whereas in nonimmune cells, ferroptosis can initiate immune responses via damage-associated molecular patterns